New LPG rates released on 1st September
LPG Price 1 Sep 2022: New LPG rates released on 1st September, check immediately

LPG Price 1 Sep 2022: LPG cylinder has become cheaper by Rs 100 from today. Commercial LPG cylinders became cheaper this month. New rates of LPG have been released by Indian Oil today i.e. on 1st September, according to which Indane cylinder will get cheaper by Rs 100 in Kolkata, Rs 92.50 in Mumbai, and Rs 91.50 in Delhi, Rs 96 in Chennai. This reduction has happened from Delhi to Patna, Jaipur to Dispur, and Ladakh to Kanyakumari.

Whereas, the domestic LPG cylinder of 14.2 kg is available at the rate of 6 July only. Let us tell you that on July 6, the prices of domestic LPG cylinders were increased by Rs 50.

Rate of 14.2 kg cylinder in rupees (in the round figure)

Leh 1299
Aizawl 1205
Srinagar 1169
Patna 1142.5
Kanya Kumari 1137
Andaman 1129
Ranchi 1110.5
Shimla 1097.5
Dibrugarh 1095
Lucknow 1090.5
Udaipur 1084.5
Indore 1081
Kolkata 1079
Dehradun 1072
Chennai 1068.5
Agra 1065.5
Chandigarh 1062.5
Visakhapatnam 1061
Ahmedabad 1060
Bhopal 1058.5
Jaipur 1056.5
BENGALURU 1055.5
Delhi 1053
Mumbai 1052.5
New rates of 19 kg commercial cylinder

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From today, a 19 kg LPG cylinder will be available in Delhi for Rs 1885 instead of Rs 1976.50. At the same time, earlier it was available in Kolkata for Rs 2095.50, but from September 1, 1995.50 it is available for Rs. The price of the commercial cylinder has come down to Rs 1844 in Mumbai and Rs 2045 in Chennai from today.

Dr Jitendra Singh
India’s first indigenously developed vaccine, “CERVAVAC” for the prevention of cervical cancer

Union Minister of State (Independent Charge) Science & Technology; Minister of State (Independent Charge) Earth Sciences; MoS PMO, Personnel, Public Grievances, Pensions, Atomic Energy and Space, Dr Jitendra Singh announces India’s first indigenously developed vaccine, “CERVAVAC” for the prevention of cervical cancer.

Announcing the scientific completion of the quadrivalent Human Papilloma Virus (qHPV) vaccine in presence of Mr. Adar C. Poonawalla, CEO, Serum Institute of India, Pune and other prominent scientists and dignitaries, Dr Jitendra Singh said, this affordable and cost- effective vaccine marks an important day for DBT and BIRAC as it takes India a step closer to PM Modi’s vision of Atmanirbhar Bharat.
Dr Jitendra Singh pointed out that Cervical cancer ranks as the 2nd most prevalent cancers in India and accounts for nearly one-fourth of the world’s cervical cancer deaths despite being largely preventable. He said, current estimates indicate that every year approximately 1.25 lakhs women are diagnosed with cervical cancer, and over 75 thousand die from the disease in India, and 83 % of invasive cervical cancers are attributed to HPVs 16 or 18 in India, and 70% of cases worldwide. The Minister said, the most promising intervention for preventing cervical cancer is vaccination against human papillomavirus (HPV). It is estimated that HPV types 16 and 18 (HPV-16 and HPV-18) together contribute to approximately 70% of all invasive cervical cancer cases worldwide.

Dr Jitendra Singh pointed out that COVID has awakened us to the virtues of preventive healthcare, particularly in a society like India having less awareness of preventive Medicare due to various socio-economic factors. He said, thanks to schemes like Ayushman, which allowed the poor, lower section of the society and the vulnerable population to indulge in the luxury of preventive medicine and preventive healthcare by getting insurance coverage of up to Rs 5 lakh.


Referring to Modi’s visit to Zydus Biotech Park in Ahmedabad, Bharat Biotech in Hyderabad and Serum Institute of India in Pune in November, 2020, to personally review the vaccine development and manufacturing process for Covid, Dr Jitendra Singh said, Prime Minister then underlined that “India considers vaccines as not only vital to good health but also as a global good, and it is India’s duty to assist other countries, including the nations in our neighbourhood, in the collective fight against the virus”.
Dr Jitendra Singh pointed out that within a year of implementation, the Mission Covid Suraksha demonstrated major achievements such as (i) Development of the World’s first DNA Vaccine for COVID-19 by Cadila Healthcare which received Emergency Use Authorization on 20 August 2021, and (ii) Supporting the development of the nation’s first mRNA Vaccine and intranasal vaccine candidate against COVID-19. He said, ‘CERVAVAC’ is an outcome of a partnership of DBT and BIRAC with the Bill and Melinda Gates Foundation, supported by Serum Institute of India Private Limited for the indigenous development of quadrivalent vaccine through its partnership programme ‘Grand Challenges India’. He said, academia, industries and research should become equal partners in the true spirit of Integrated Approach for result-oriented products.


The Minister said that the Department of Biotechnology (DBT) has made strenuous efforts to strengthen the Indian vaccine research and development over the past three decades. He added that a number of key initiatives are currently being implemented to promote basic and translational vaccine research, including the (i) Indo-US Vaccine Action Programme, (ii) National Biopharma Mission, (iii) Ind-CEPI Mission, and (iv) Mission COVID Suraksha, which was launched as part of Atmanirbhar Bharat 3.0, with the goal of bringing safe, efficacious, affordable and accessible indigenous COVID 19 vaccines to the citizens of the country at the earliest.

Read Also: Hydration of proteins could act as a potential marker for an early detection of neuro-degenerative diseases

Dr Rajesh Gokhale, Secretary, DBT said, this is a celebration of collective efforts of all stakeholders and added that partnerships with industries are becoming incredibly important for doing R&D, which requires huge funding. He said, India will take a lead in vaccine development and medicine by breaking all barriers for betterment of mankind.


Dr N. Kalaiselvi, DG, CSIR in her address said that the cancer vaccine will help Indian women and women across the globe in major way and we may see in near future the version 1, 2 and 3 of “CERVAVAC”, as technologies are short lived. She said, “India Can Do” and added that we will come out with Indian solutions to Indian problems in true spirit of Atmanirbharta.


Mr. Adar C. Poonawalla, CEO, Serum Institute of India, Pune said in his brief address said that well being and protection of mother and child is the core philosophy of Serum Institute as only a healthy India can be a productive India. He also supported DBT’s vision for more collaboration between Private and Government sectors for manufacturing of vaccines and drugs in India.


Noted film actress Manisha Koirala, who bravely fought and won the battle against ovarian cancer joined virtually to thank the Ministry of Science and Technology and particularly DBT for reaching this milestone. She said, this a great day for women in India and women world over, as there is life beyond cancer. She said, cost effective preventive treatment will inspire millions of such patients to say “Yes to Life”.
Dr. Alka Sharma, Senior Adviser, DBT and MD, BIRAC gave the welcome address, while Dr Shirshendu Mukherjee, Mission Director, Grand Challenges India and In-Charge, Mission COVID Suraksha, BIRAC delivered the vote of thanks.


Dr. Neerja Bhatla, Prof., Gynaecology and Obstetrics, AIIMS, New Delhi, Dr. N. K. Arora, INCLEN Trust, New Delhi, Dr. Umesh Shaligram, Executive Director, Serum Institute of India, Pune, Dr. Guruprasad R. Medigeshi, Asst. Prof., THSTI, Faridabad, Dr. Devasena Anantharaman, Scientist, RGCB, Thiruvananthapuram also took part in the event.

detection of neuro-degenerative diseases
Hydration of proteins could act as a potential marker for an early detection of neuro-degenerative diseases

SEO Friendly Content Writer: Hydration dynamics of proteins plays a pivotal role in the aggregation of several proteins which is a preliminary step towards various neuro-degenerative diseases. Thus aggregation process could be spotted early by detecting altering water network dynamics and modulated using inactive substances that serve as the vehicle or medium for a drug or other active substance.


Understanding debilitating neuro-degenerative diseases at the molecular level is crucial to find treatments or solutions for them. A phenomenon called ‘liquid liquid phase separation’ (LLPS) underlines the formation of cells organelles like P bodies, nucleolus which are membrane-less compartments in the cytoplasm of cells. LLPS, a self-aggregated system, is an intermediate step during the formation of the stable protein aggregates. When multivalent proteins interact they undergo rapid transformation from small complexes to large polymeric assemblies with increase in protein concentration. This dense phase often resembles liquid droplets exhibiting higher protein density and weaker molecular motion than the surrounding medium. This process, initiated through liquid liquid phase transfer, plays crucial role in inducing human diseases, especially age-related neuro-degenerative diseases like Alzheimer’s disease, Parkinson’s disease and cataract. Therefore, understanding the process of phase separation at a molecular level has become an emergent area of research in molecular biology fraternity.


Scientists at the S.N Bose National Centre for Basic Sciences, an autonomous institute of the Department of Science and Technology (DST) have explored how the hydration of proteins, gets altered as LLPS sets in. The researchers have spotted the crucial role of water in Liquid liquid phase separation which holds the key to neuro-degenerative diseases. They found that some excipients or inactive substance that serves as the vehicle or medium for a drug or other active substance like sucrose can stabilise LLPS while some can inhibit it. Thus aggregation process of these diseases could be modulated by altering water network dynamics using these excipients.

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In a paper published in J. Phys. Chem. Lett the scientists, under the leadership of Prof. Rajib Kumar Mitra, examined four excipients —arginine, glucose, ubiquitin, and bovine serum albumin. Some excipients like sucrose were found to stabilize the LLPS process while Bovine Serum Albumen (BSA) was found to inhibit the process.


Their experiments have identified that both protein and excipient hydration are important in regulating the LLPS process. Monitoring a change in hydration could therefore act as a potential marker for an early and easy detection of LLPS onset.


Publication link:https://doi.org/10.1021/acs.jpclett.1c03449
For more details, contact Prof. Rajib Kumar Mitra, Email : rajib@bose.res.in .

Microscopic image of Lys under different conditions
Figure 1:Microscopic image of Lys under different conditions: (a) No phase separation, (b) only Lys (600 μM), (c) Lys−100 mM Argsolution, (d) Lys−10 mM sucrose solution, (e) Lys−50 μM BSA solution, and (f) Lys−100 μM Ubi solution. All of the measurements were carriedout after 6 h of incubation at 50 °C. The concentration of Lys was kept fixed at 600 μM, and the pH of the solution was 12.6.

Figure 2. Relative change in the overall hydration during the LLPS formation of Lysozyme in presence of excipients (considering LLPS in Lys as the unity for both HB stretching and librational mode).

Relative change in the overall hydration during